- Copilot AnswerWatch full videoStructure
The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. In addition, both complexes are derived from the same f… See more
Activin-A in the regulation of immunity in health and disease
Here, we provide an overview of the biology of activin-A and its signaling pathways, summarize recent studies pertinent to the role of activin-A in the modulation of inflammation and immunity, …
- Author: Ioannis Morianos, Gina Papadopoulou, Maria Semitekolou, Georgina Xanthou
- Publish Year: 2019
Activin A - an overview | ScienceDirect Topics
Activin A is a growth factor that regulates bone metabolism, male reproduction, liver regeneration and pain sensation. Learn about its structure, signaling, functions and clinical applications from …
Activins and Inhibins: Roles in Development, …
First identified as regulators of follicle-stimulating hormone secretion and erythropoiesis, activin and inhibin are involved in diverse processes during development and in terminally differentiated cells and tissues.
Different Immunoregulation Roles of Activin A …
Jun 14, 2022 · Activin A is a TGF-β superfamily member that affects various immune cells and diseases. This review summarizes its signaling pathway, functions and differences with TGF-β in the immune system.
The Biology Of Activin: Recent Advances In Structure, Regulation …
Activin was discovered in the 1980’s as a gonadal protein that stimulated FSH release from pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing decades …
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Activin A in Mammalian Physiology - PubMed
Jan 1, 2019 · In particular, activin A was shown to be the isoform of greater physiological importance in humans. The current understanding of activin A surpasses the reproductive …
Activin A skews macrophage polarization by promoting …
May 12, 2011 · Activin A, which is synthesized by monocytes/macrophages in response to LPS, 18 TNFα, or IL-1β, 49 exhibits both pro- and anti-inflammatory activities 18 because it stimulates the production of IL-1 and TNFα by human …
Activin A: an emerging target for improving cancer …
Aug 6, 2020 · Activin A has growth- and migration-promoting effects, contributes to immune evasion and cachexia and is associated with shorter survival in several cancer types.
Activin A: an emerging target for improving cancer treatment?
Targeting activin A could offer the chance to simultaneously limit tumor growth and spreading, improve drug response, boost antitumor immune responses and improve cancer-associated or …
