Jun 29, 2020 · Functionally, ACOD1 mediates itaconate production, oxidative stress, and antigen processing and plays dual roles in immunity and diseases. On the one hand, activation of the …

In this review, we discuss the latest research advances in ACOD1 expression and function, with particular attention to how the ACOD1-itaconate pathway affects infection and sterile …

Schofield et al. report that cancer cells upregulate Acod1 as a survival strategy in response to αPD-1 therapy. Acod1hi cancer cells secrete inhibitory peptides that block the activation of …

Schofield et al. report that cancer cells upregulate Acod1 as a survival strategy in response to PD-1 therapy. Acod1hi. cancer cells secrete inhibitory peptides that block the activation of naive …

Feb 20, 2024 · In the IMQ-induced mouse model of lupus, ACOD1 knockout (Acod1 −/−) displayed disruptions of the splenic architecture, increased serum anti-dsDNA and …

Functionally, ACOD1 mediates itaconate production, oxidative stress, and antigen processing and plays dual roles in immunity and diseases. On the one hand, activation of the ACOD1 pathway …

Sep 18, 2023 · We show that ACOD1 knockout macrophages, generated in our induced pluripotent stem cell-derived CAR-macrophage (CAR-iMAC) platform, are strongly and …

Sep 14, 2023 · Our study suggests that strategies to counter the activity of Acod1 in cancer cells may sensitize tumors to ICB therapy. The exploitation of the immune system to target cancer …

Wet-lab research encompassing biochemical assays, cellular studies, and small animal models gradually unmasked ACOD1 as a predominantly anti-inflammatory gene and ITA as a …

Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging as a …