This review provides a comprehensive account of the control of p53 acetylation and its effects on p53 transcription and cell fate, with a focus on its acetyltransferases and their regulators, as well as the effect of other post-translational modifications on p53 acetylation.

Apr 29, 2022 · Here, we review the role of acetylation in p53-mediated activities, with a focus on which specific acetylation sites are critical for p53-dependent transcription regulation during tumor...

Although the acetylation of p53 has been examined, the underlying regulatory mechanisms remain unclear and, thus, have attracted the interest of researchers. We herein discuss the role of acetylation in the p53 pathway, with a focus on p53 acetyltransferases and deacetylases.

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence.

May 5, 2008 · Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response.

Sep 14, 2016 · SET profoundly inhibits p53 transcriptional activity in unstressed cells, but SET-mediated repression is abolished by stress-induced acetylation of p53 CTD. Moreover, loss of the interaction with...

Dec 23, 2014 · This review discusses the cumulative findings regarding p53 acetylation, with a focus on the acetyltransferases that modify p53 and the mechanisms regulating their activity.

As a "genomic guardian", p53 mainly functions as a transcription factor that regulates downstream targets responsible for cell fate control, and the activity of p53 is tightly regulated by a complex network that include an abundance of post-translational modifications.

Oct 4, 2016 · Here, we have identified an acetylation site at lysine K98 in mouse p53 (or K101 for human p53). Whereas the loss of K98 acetylation (p53 K98R) alone has very modest effects on p53-mediated transactivation, simultaneous mutations at all four acetylation sites (p53 4KR: K98R+ 3KR[K117R+K161R+K162R]) completely abolish its ability to regulate ...

This review summarizes what is known of p53 acetylation, including the initial discovery, acetylation sites on p53, enzymes involved, functional consequences in p53 transcriptional activity, overall physiological significance or biological outcomes, and molecular mechanisms.