Feb 20, 2024 · Our results indicated that SARS-CoV-2 up-regulated ACE2 expression by activating the transcription factor SP1, while concurrently inhibiting HNF4α via the PI3K/AKT …

Feb 20, 2024 · The PI3K/AKT signaling pathway, activated by SARS-CoV-2 infection, served as a crucial regulatory node, inducing ACE2 expression by enhancing SP1 phosphorylation-a …

ACE2 expression by enhancing SP1 phosphorylation—a marker of its activity—and reducing the nuclear localization of HNF4α. However, colchicine treatment inhibited the PI3K/AKT signaling

Feb 14, 2023 · Inhibition of Sp1 by either its inhibitor mithramycin A or colchicine reduces viral replication and tissue injury in Syrian hamsters infected with SARS-CoV-2. In summary, our …

Feb 20, 2024 · Either knockdown of SP1 or inhibition of PI3K significantly suppressed the levels of ACE2 in HPAEpiCs. The blot is typical of three independent experiments (A). Quantification …

Feb 14, 2023 · During SARS-CoV-2 infection, the spike protein binds with ACE2 and. 55 essential for viral entry (Hoffmann et al., 2020). ACE2 is wildly expressed in the lung, small. 56 intestine, …

ACE2 receptors on the surface of host cells recognize S1 glycoprotein, which contains receptor binding domain (RBD), and TMPRSS2 primes S2, containing fusion peptide. It can achieve …

Feb 20, 2024 · This study uncovers a novel function of SP1 in the regulation of ACE2 expression and identifies SP1 as a potential target to reduce SARS-CoV-2 infection. Angiotensin …

The PI3K/Akt signaling pathway, activated by SARS-CoV-2 Infection, served as a crucial regulatory node, inducing ACE2 expression by enhancing SP1 phosphorylation-a marker of its …

Feb 14, 2023 · By employing an array of 45 different luciferase reporters, we identify that the transcription factor Sp1 positively and HNF4α negatively regulate the expression of ACE2 at …