Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene. [5][6][7] ABI2 has been shown to interact with ABL1, [5][8] ADAM19, [9] and TRIM32. [10] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

Double knockout of c-Cbl and Cbl B in Bcr-Abl-transformed leukemic cells abolishes Abi1, Abi2, and WAVE2 degradation. Moreover, knockout of Abi1 reduces Src family kinase Lyn activation in Bcr-Abl-positive leukemic cells and promotes EGF-induced EGF receptor downregulation in breast cancer cells.

Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl. A basic region in the amino terminus of Abi-2 is homologous to the DNA-binding sequence of homeo-domain proteins.

ABI2 has been shown to function as a tumour suppressor in chronic myeloid leukaemia with inhibitory function of c‐Abl signalling. 28 In another study, the characteristics of the Abi‐2 protein were consistent with a dual role as a regulator and potential effector of the c‐Abl protein.

Mar 28, 2025 · ABI2 (Abl Interactor 2) is a Protein Coding gene. Diseases associated with ABI2 include Developmental And Epileptic Encephalopathy 65 and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2H. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Signaling by Rho GTPases.

Nov 1, 1995 · Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl. A basic region in the amino terminus of Abi-2 is homologous to the DNA-binding sequence of homeo-domain proteins. We show that Abi-2 …

Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl. A basic region in the amino terminus of Abi-2 is homologous to the DNA-binding sequence of homeo-domain proteins. We show that Abi-2 is a substrate for the c …

Jan 1, 2024 · In this study, we found that the Drosophila BRAG GEF Schizo interacts physically with the Abl-interactor (Abi). schizo mutants display severe defects in myoblast fusion during syncytial muscle formation and show increased amounts of the cell adhesion protein N-cadherin.

Nov 2, 2007 · In this study, we found PTP61F, a Drosophila homolog of mammalian PTP1B, can reverse the Abl phosphorylation of Abi and colocalizes with Abi in Drosophila S2 cells. Abi can be translocalized from the cytosol to the cell membrane by either increasing Abl or reducing endogenous PTP61F.

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