In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]).

Nov 1, 2024 · AUC in pharmacokinetics (Area Under the Curve) is a vital parameter of the plasma level time curve. AUC is also known as the zero moment curve. It is a crucial measure of the bioavailability of a drug after administration.

The area under the concentration vs. time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. This page summarizes the calculations and terminology that may be encountered.

The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the …

Following single intravenous doses, AUC = D/ClT, for single compartment systems obeying first-order elimination kinetics; alternatively, AUC = C0/kel. With routes other than the intravenous, for such systems, AUC = F · D/ClT, where F is the bioavailability of the drug.

Nov 12, 2018 · What is accuracy, precision, recall, specificity and F score; How to calculate and interpret these measures; How to construct a confusion matrix; What is the AUC score and its interpretation; How to get confusion matrix and classification report in sklearn

Nov 7, 2014 · AUC is of dimension [PRECISION]*[RECALL] and it is the area under ROC curve. F1 is for a fixed pair of precision and recall. So they are different. But there are some connections. See this: http://pages.cs.wisc.edu/~jdavis/davisgoadrichcamera2.pdf

Jan 30, 2024 · Clearance of drug from the absorption site must be significantly greater than clearance following an iv bolus dose for F (AUC) to correctly correspond with F (urine). The primary purpose of this paper is to demonstrate that studies resulting in F > 1.0 and/or greater systemic vs urine bioavailability predictions may be accurate.

Calculation of oscillation requires ability to estimate peak and trough at SS. Then use old standby for predicting Cp (t), but now "t" is defined as "T", the dose interval. Using liquid dose forms has theoretical advantage of allowing "continuously variable" dosing.

The area under the plasma drug concentration time curve (AUC) is then determined for each route of administration and the bioavailability is the ratio of AUC oral to AUC intravenous (F = AUC oral / AUC intravenous). The most common reasons for a reduced bioavailability are drug interactions, altered drug metabolism, variation in drug ...