Boosting ATM activity alleviates aging and extends lifespan in a …
May 2, 2018 · Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of Sirt6 extend lifespan in …
- Author: Minxian Qian, Zuojun Liu, Linyuan Peng, Xiaolong Tang, Fanbiao Meng, Ying Ao, Mingyan Zhou, Ming Wan...
- Publish Year: 2018
Other content from pubmed.ncbi.nlm.nih.govBoosting ATM activity alleviates aging and extends …
May 2, 2018 · Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of …
- Author: Minxian Qian, Zuojun Liu, Linyuan Peng, Xiaolong Tang, Fanbiao Meng, Ying Ao, Mingyan Zhou, Ming Wan...
- Publish Year: 2018
ATM and SIRT6/SNF2H Mediate Transient H2AX …
Dec 29, 2015 · H2AX stabilization is mediated by the ATM kinase, sirtuin protein SIRT6, and ISWI family chromatin remodeler SNF2H. This enables efficient …
- Author: Yuko Atsumi, Yusuke Minakawa, Masaya Ono, Sachiko Dobashi, Keitaro Shinohe, Akira Shinohara, Shunich...
- Publish Year: 2015
SIRT6 Through the Brain Evolution, Development, and Aging
Oct 13, 2021 · Sirt6 can bind directly to broken DNA, and initiate the DSB repair pathway by the recruitment of other repair proteins such as ATM, PARP1, Mre11, and Ku80/70. Human/Mice …
- Author: Alfredo Garcia-Venzor, Debra Toiber
- DOI: 10.3389/fnagi.2021.747989
- Publish Year: 2021
- Publication: Front Aging Neurosci. 2021; 13: 747989.
SIRT6, a Mammalian Deacylase with Multitasking Abilities
Oct 30, 2019 · Another study in C. elegans deficient for the DNA repair factor Atm, which display reduced lifespan, increased copies of Sirt6 restore lifespan and metabolic homeostasis . …
- Author: Andrew R. Chang, Christina M. Ferrer, Raul Mostoslavsky
- Publish Year: 2020
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ATM and SIRT6/SNF2H Mediate Transient H2AX ... - ScienceDirect
Dec 29, 2015 · H2AX Ser139, the ATM phosphorylation site, was essential for H2AX stabilization upon DSB formation. Our results reveal a pathway controlled by ATM, SIRT6, and SNF2H to …
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks …
We show that a K33R mutation that mimics hypoacetylated SIRT6 can rescue defective DNA repair as a result of SIRT1 deficiency in cultured cells. These data highlight the synergistic …
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ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When ... - PubMed
Dec 29, 2015 · H2AX Ser139, the ATM phosphorylation site, was essential for H2AX stabilization upon DSB formation. Our results reveal a pathway controlled by ATM, SIRT6, and SNF2H to …
Our results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
May 28, 2021 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in …
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