Atg2 mediates direct lipid transfer between membranes for
Mar 25, 2019 · Atg2 bridges highly curved liposomes, thereby facilitating efficient phospholipid transfer in vitro, a function that is inhibited by mutations that impair autophagosome formation …
Mammalian Atg2 proteins are essential for autophagosome …
Mammalian Atg2 proteins Atg2A and Atg2B are identified and characterized as essential for autophagy. They are also present on lipid droplets and are involved in regulation of lipid …
Atg2: A novel phospholipid transfer protein that mediates de novo ...
Recent advances in structural and biochemical analyses have been applied to Atg2 and have revealed it to be a novel multifunctional protein that tethers membranes and transfers …
Atg2: A novel phospholipid transfer protein that mediates de …
Recent advances in structural and biochemical analyses have been applied to Atg2 and have revealed it to be a novel multifunctional protein that tethers membranes and transfers …
ATG2 transports lipids to promote autophagosome biogenesis
Jun 3, 2019 · Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the ER …
ATG2 transports lipids to promote autophagosome biogenesis
Jun 6, 2019 · Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the …
Mammalian Atg2 proteins are essential for autophagosome …
Autophagosome formation is considered to take place on the endoplasmic reticulum and involves functions of autophagy-related (Atg) proteins. Here, we report the identification and …
Structural basis for lipid transfer by the ATG2A–ATG9A complex
Aug 2, 2024 · Autophagy-related proteins (ATGs) 2A and 9A have an essential role in autophagy by mediating lipid transfer and re-equilibration between membranes for autophagosome …
ATG2 and VPS13 proteins: molecular highways transporting lipids …
Nov 16, 2021 · We discuss the recent biochemical and structural advances that have highlighted the essential role Chorein-N domain containing ATG2 proteins play in driving the formation of …
The Atg2-Atg18 complex tethers pre-autophagosomal …
Here we describe two membrane-binding domains responsible for autophagosome formation in the autophagy-related protein Atg2, which localizes to the pre-autophagosomal membrane–ER …