Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway.

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. ASK1 is preferentially activated by various cytotoxic stressors and plays pivotal roles in a wide variety of cellular response to them.

ASK1 is a member of the large MAPK kinase kinase (MAP3K) family that activates downstream MAPKs, c-Jun N-terminal kinases (JNKs) and p38 MAPKs, and it plays a pivotal role in various stress responses, including cell death, differentiation, and production of …

However, apoptosis signal-regulating kinase 1 (ASK1), an upstream regulator of P38 and JNK, has emerged as an alternative drug target for limiting P38- and JNK-mediated disease. Within this review, we compile the evidence that ASK1 mediates damaging cellular responses via prolonged P38 or JNK activation.

Jun 5, 2024 · Here, we show that the stress-responsive kinase apoptosis signal-regulating kinase 1 (ASK1) promotes inflammation in senescence and aging. ASK1 is activated during senescence and...

ASK1 (apoptosis signal-regulating kinase 1), a MKKK (mitogen-activated protein kinase kinase kinase), is activated in response to cytotoxic stresses, such as H 2 O 2 and TNFα (tumour necrosis factor α). ASK1 induction initiates a signalling cascade leading to apoptosis.

Apoptosis signal-regulating kinase 1 (ASK1, also known as MAP3K5), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, activates the p38 mitogen-activated protein kinase and the c-Jun N-terminal kinase (JNK) …

Sep 4, 2018 · Apoptosis signal–regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine kinase that activates p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase kinases, and induces apoptotic, inflammatory, and fibrotic signaling in settings of oxidative stress.

Dec 20, 2013 · ASK1 is a mitogen-activated protein kinase kinase kinase (MAPKKK, MAP3K) that is preferentially activated by oxidative stress and inflammation. ASK1 has been linked to the fundamental pathology of brain damage in stroke and has essential roles in various cellular responses, such as apoptosis, cell differentiation and immune responses.

Dec 15, 2023 · ASK1 is activated by forming an “ASK1 signal body” with TRAF family proteins in response to oxidative stress, and it is also involved in TNF-α induced cell apoptosis pathway. TNF-α is a proinflammatory cytokine, which plays an important role in immune response.