Sep 4, 2018 · SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts. ASCT2 is an acronym standing for Alanine, Serine, Cysteine Transporter 2 even if the preferred substrate is the conditionally essential amino acid …

Dec 10, 2019 · In this study, ASCT2, an amino acid transporter responsible for glutamine transport, in addition to LAT1 and GLS, is overexpressed in HNSCC and associated with poor survival.

Jun 16, 2016 · Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells.

Sep 4, 2018 · SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts.

Jan 13, 2024 · ASCT2(SLC1A5) is the main glutamine transporter in tumor (Fig. 1). It is regulated by multiple tumor associated transcription factors including Rb/E2F [ 15 ], androgen receptor 3 [ 16 ] and...

Jan 13, 2024 · Alanine-serine-cysteine transporter 2 (ASCT2) is up-regulated in lung cancers, and inhibiting it could potentially lead to nutrient deprivation, making it a viable strategy for cancer treatment. In this study, we present a series of ASCT2 inhibitors based on aminobutanoic acids, which exhibit potent inhibitory activity.

Oct 15, 2018 · ASCT2 (alanine-serine-cysteine transporter 2; SLC1A5), an Na +-dependent neutral amino acid transporter encoded by the SLC1A5 gene, is predominantly localized in the cell membrane. It mediates the exchange of amino acid substrates, which is crucial for the uptake of glutamine by rapidly growing tumor cells (Kekuda et al., 1996).

Oct 15, 2018 · In conclusion, this review describes the function, regulatory mechanism, and inhibitors of ASCT2 in cancer, suggesting that high expression of ASCT2 is a promising prognostic marker and a potential drug target.

Jun 5, 2018 · Human ASCT2 belongs to the SLC1 family of secondary transporters and is specific for the transport of small neutral amino acids. ASCT2 is upregulated in cancer cells and serves as the...

Here, we characterize the amino acid transporter ASCT2 (coded for by the gene SLC1A5) as the primary serine transporter in cancer cells. ASCT2 is well-known as a glutamine transporter in cancer, and our work demonstrates that serine and glutamine compete for …