WORK BASED LEARNING EXPERIENCES (WBLE) is a structured work study transition service that utilizes community-based transition instruction for neurodiverse 18-22 year old students who have met graduate requirements and elect to defer their standard diploma using the Individualized Education Plan (IEP) process.

Mar 20, 1998 · The INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF arrests the cell cycle in a p53-dependent manner. We show here that ARF binds to MDM2 and promotes the rapid degradation of MDM2.

ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely ...

Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function. The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53.

Oct 1, 2001 · Arf is activated by oncogenic signals, such as Myc overexpression or constitutive Ras activation. By activating p53, p19 Arf diverts incipient cancer cells to alternative fates — either to...

ARF WIDE builds a talent pipeline for companies that strive for equity and inclusion among their ranks. Training Program orients Scholars to the ecosystem and provides technical skill-building Learning Labs.

Jun 14, 2010 · ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing evidence that ARF signaling is complex, and involves p53-dependent or -independent pathways aiming mainly at restraining abnormal cell growth and at maintaining genomic stability.

Aug 4, 2020 · In this review, we mainly focused on how cancer cells employ transcriptional and post-translational regulatory mechanisms to manipulate ARF activities to circumvent the tumor-suppressive function of ARF. We further discussed the clinical implications of …

Jan 1, 2017 · ARF (alternative reading frame) is a tumor suppressor protein that accumulates in the nucleolus in response to aberrant oncogenic/hyperproliferative signals and induces cell cycle arrest in G1/S or G2/M transition and apoptosis.

Jun 21, 2013 · Acute rheumatic fever (ARF) is an autoimmune phenomenon that occurs after infection with group A streptococcus. Inflammation of the joints, heart, and brain results in the common clinical manifestations of arthritis, carditis, and chorea.