APN MMP-1 - Search

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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
MMP activation–associated aminopeptidase N reveals a bivalent …
Aminopeptidase N (APN, CD13) is a transmembrane ectopeptidase involved in many crucial cellular functions. Besides its role as a peptidase, APN also mediates signal transduction and …
PubMed
https://pubmed.ncbi.nlm.nih.gov
14-3-3 sigma associates with cell surface aminopeptidase N in the ...
Sep 1, 2010 · The presence of a phosphorylated serine or threonine residue in APN has been implicated. Together, these findings provide evidence that APN is a novel cell surface receptor …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
A Profiling Platform for the Identification of Selective ...
For this purpose, we tested the activity of a panel of 8 commercially available MPIs at 3 concentrations—100, 10, and 1 μM against APN, MMP-1, MMP-2, MMP-9, E. coli PDF …
- Author: Christophe Antczak, Constantin Radu, Hakim Djaballah
- DOI: 10.1177/1087057108315877
- Publish Year: 2008
- Published: 2008/04
Studies of APN MMP-1
PubMed
14-3-3 sigma associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1
Matrix metalloproteinases (MMPs) are implicated in the degradation of the extracellular matrix during development and tissue repair, as well as in pathological conditions such as tumor invasion and fibrosis. MMP expression by stromal cells is partly regulated by signals from the neighboring epitheli...
Author: Abdi Ghaffari
Published: 2010/09/01
Keywords: National In…
National Center for Biotechnology Information
A Profiling Platform for the Identification of Selective Metalloprotease Inhibitors
Although proteases represent an estimated 5% to 10% of potential drug targets, inhibitors for metalloproteases (MPs) account for only a small proportion of all approved drugs, failures of which have typically been associated with lack of selectivity. In this study, the authors describe a novel and u...
Author: CHRISTOPH…
Published: 2008/04
DOI: 10.1177/1087057…
ScienceDirect
Minireview The AP-1 site and MMP gene regulation: What is all the fuss about?
Matrix metalloproteinase (MMP) gene expression occurs under tightly regulated mechanisms that lead to cell and tissue-specific expression of the individual genes. Despite this differential expression,there exists a high degree of similarity among the cis-acting elements in the MMP promoters.The Acti...
Published: 1997/03/01
Cited By: 0
Keywords: matrix met…
physoc.onlinelibrary.wiley.com
Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice
Adiponectin (APN) is a multifunctional adipocytokine that inhibits myocardial fibrosis, dilatation, and left ventricular (LV) dysfunction after myocardial infarction (MI). Coxsackievirus B3 (CVB3) myocarditis is associated with intense extracellular matrix (ECM) remodeling which might progress to di...
Author: Alexander Jen…
Published: 21 Decemb…
Cited By: 14
PubMed
Microarray-based identification of aminopeptidase N target genes in keratinocyte conditioned medium-stimulated dermal fibroblasts
Of the many processes that affect the outcome of wound repair, epidermal-dermal interactions are essential to extracellular matrix (ECM) remodeling and in particular, soluble factors released by keratinocytes are known to have a direct impact on the production of ECM by dermal fibroblasts. Aminopept...
Author: Amy Lai
Published: 2012/3
Keywords: National In…
ScienceDirect
Novel 3-galloylamido-N′-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors
Both of aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. Novel potent peptidomimetic inhibitors, containing 3-galloylamido-N′-substituted-2,6-piperidinedione-N-acetamide, have been designed and synthesize...
Published: 2007/05/15
Cited By: 0
Keywords: Aminopepti…
PubMed
MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif
Aminopeptidase N (APN, CD13) is a transmembrane ectopeptidase involved in many crucial cellular functions. Besides its role as a peptidase, APN also mediates signal transduction and is involved in the activation of matrix metalloproteinases (MMPs). MMPs function in tissue remodeling within the extra...
Author: Sebastian Kie…
Published: 2020/12/25
Keywords: 14-3-3 prot…
PubMed
The AP-1 site and MMP gene regulation: what is all the fuss about?
Matrix metalloproteinase (MMP) gene expression occurs under tightly regulated mechanisms that lead to cell and tissue-specific expression of the individual genes. Despite this differential expression, there exists a high degree of similarity among the cis-acting elements in the MMP promoters. The Ac...
Author: U Benbow
Published: 1997/3
Keywords: National In…
ScienceDirect
Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation
Recent profiling has identified the aminopeptidase N/CD13 inhibitor actinonin as a selective soluble secreted matrix metalloproteinase (MMP) inhibitor. Given that actinonin’s effects against membrane-bound MMPs remain unknown and that MT1-MMP has been linked to chemo- and radio-therapy resistance in...
Published: 2009/07/08
Cited By: 0
Keywords: APN amino…
UBC Library Open Collections
https://open.library.ubc.ca › soa › cIRcle › collections › ubctheses › items
Role of aminopeptidase N in wound healing
Our group has demonstrated that 14-3-3 sigma (also known as stratifin) functions as a stimulator of matrix metalloproteinase-1 (MMP-1) through interactions with aminopeptidase N (APN) on …
- Creator: Lai, Amy M.
- Publisher: University of British Columbia
- Date Issued: 2011
- Title: Role of aminopeptidase N in wound healing
ScienceDirect
https://www.sciencedirect.com › science › article › pii
The AP-1 site and MMP gene regulation: What is all the fuss about?
Mar 1, 1997 · The rabbit MMP-1 gene with a mutation in the AP-1 site responds to PMA as long as 321 bp of the promoter are present (White and Brinckerhoff, 1995). Furthermore, both the …
- Author: Ulrike Benbow, Constance E. Brinckerhoff
- Publish Year: 1997
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Semantic Scholar
https://www.semanticscholar.org › paper
[PDF] 14-3-3σ associates with cell surface aminopeptidase N in the ...
Sep 1, 2010 · The presence of a phosphorylated serine or threonine residue in APN has been implicated. Together, these findings provide evidence that APN is a novel cell surface receptor …
People also ask
Does AP1 repress MMPs?
On the other, the AP 1 site plays a dominant role in repression of MMPs by transforming growth factor β (TGF-β), retinoids and glucocorticoids, although some AP-1 independent mechanisms may also contribute. While the AP-1 site is involved in tissue-specific expression of MMPs, the presence of one or more AP-2 elements appears critical.
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
Does AP-1 regulate MMP-7 (Matrilysin)?
The AP-1 site also regulates the MMP-7 (matrilysin) pro- moter, with apparent cooperation between AP- 1 and PEA3. The AP-1 site at -67 bp interacts with two adjacent PEA3 elements, located at -146 bp and -170 bp, to confer PMA responsiveness (Gaire et al., 1994).
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
Which AP1 site is important for repression of MMPs?
Particularly important are PEA3 sites, located either adjacent to this AP-1 site or more distally. On the other, the AP 1 site plays a dominant role in repression of MMPs by transforming growth factor β (TGF-β), retinoids and glucocorticoids, although some AP-1 independent mechanisms may also contribute.
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
Does AP-1 regulate transcription of MMPs?
Thus, the AP-1 site, alone, does not regulate transcription of MMPs. Rather, there is an essential interaction with other cis-acting sequences in the promoters and with certain transcription factors that bind to these sequences.
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
What is matrix metalloproteinase (MMP) gene expression?
Matrix metalloproteinase (MMP) gene expression occurs under tightly regulated mechanisms that lead to cell and tissue-specific expression of the individual genes.
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
Are AP-1 and AP-2 essential for MMP inducibility in primary epithelial cells?
Similarly, in the rabbit MMP-9 pro- moter, the AP-1 site at - 56 bp and an AP-2 like element lo- cated between -432 bp and -330 bp are essential for PMA inducibility in primary epithelial cells (Fini et al., 1994). A role for AP-I and AP-2 in tissue specific expression is not limited to MMP promoters.
The AP-1 site and MMP gene regulation: What is all the fuss about?
sciencedirect.com
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ScienceDirect
https://www.sciencedirect.com › science › article › pii
Novel 3-galloylamido-N′-substituted-2,6-piperidinedione-N …
May 15, 2007 · Both of aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. Novel …
Springer
https://link.springer.com › article
The role of AP-1 in matrix metalloproteinase gene expression
In an effort to understand the mechanism of matrix metalloproteinase (MMP) induction, lapine synoviocytes were isolated and incubated with phorbol myristate acetate (PMA) and autocrine …
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nih.gov
https://pubmed.ncbi.nlm.nih.gov
MMP activation-associated aminopeptidase N reveals a …
Dec 25, 2020 · Aminopeptidase N (APN, CD13) is a transmembrane ectopeptidase involved in many crucial cellular functions. Besides its role as a peptidase, APN also mediates signal …
The Physiological Society - Wiley Online Library
https://physoc.onlinelibrary.wiley.com › doi › full
Adiponectin attenuates profibrotic extracellular matrix remodeling ...
Dec 21, 2017 · APN has recently been demonstrated to up-regulate expression of MMP-1, MMP-3, and MMP-13 in human chondrocytes (Kang et al. 2010; Tong et al. 2011) and synovial …
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