Feb 19, 2020 · APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this complex is inhibited. However, …

Oct 4, 2018 · ICAT blocks β-catenin-APC interaction and prevents β-catenin-mediated APC-Axin interaction, enhancing stabilization of β-catenin in cells harboring truncated APC or stimulated …

The expression of adenomatous polyposis coli 2 (APC2), an inhibitor of the Wnt/β-catenin pathway, was suppressed by SMYD2 overexpression. Overexpression of SMYD2 activated …

APC binds β-catenin and is involved in the Axin complex, suggesting that APC regulates β-catenin phosphorylation. Some evidence also suggests that APC regulates β-catenin nuclear …

Aug 17, 2000 · APC suppresses tumour progression by promoting degradation of the oncogenic transcriptional activator β-catenin. APC gene mutations can lead to abnormally high levels of β …

Oct 3, 2016 · Both adenomatous polyposis coli (APC) and APC2 can regulate β-catenin/Wnt signaling 12, 13, 14 and both are expressed in human mammary epithelium. 15, 16, 17 …

Jan 28, 1999 · In colon carcinoma cells, loss of APC leads to the accumulation of βcatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1,2]. Here, …

Nov 11, 2001 · APC binds to β-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid β-catenin binding repeat …

Feb 25, 2019 · Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in embryonic and post-embryonic development across the animal kingdom. As a …

Here we test these models by generating a Drosophila APC2 mutant lacking all β-catenin-binding 20Rs and performing functional studies in human colon cancer cell lines and Drosophila …