Heterotetrameric clathrin Adaptor Protein complexes (APs) orchestrate the formation of coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes enriched …

May 17, 2002 · These observations suggest that AP1 may bind preferentially to phospholipid headgroups with fewer phosphate substituents than possessed by PIP2. Such a phospholipid …

AP-1 is localized to TGN and REs, and mediates bidirectional transport between them. AP-1 also mediates basolateral sorting in epithelial cells. AP-2 plays a role in clathrin-dependent …

Jul 22, 2020 · Here, we used cryo–electron microscopy, tomography, and subtomogram averaging to determine structures, interactions, and arrangements of clathrin and AP2 at the …

AP1 is responsible for the transport of lysosomal hydrolases between the trans-Golgi network, and endosomes. [6] AP2 adaptor complex associates with the plasma membrane and is …

Here, we briefly review the functions of three phosphoinositides, PI4P, PI (4,5)P2, and PI (3,4,5)P3, in cellular signaling and exocytosis, focusing on hormone-producing pituitary cells. …

Oct 1, 2021 · AAGAB promotes AP1 assembly by binding and stabilizing the γ and σ subunits of AP1, and its mutation abolishes AP1 assembly and disrupts AP1-mediated cargo trafficking.

It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers. These …

These observations suggest that AP1 may bind preferentially to phospholipid head-groups with fewer phosphate substituents than pos-sessed by PIP2. Such a phospholipid may be …

Aug 8, 2003 · We propose that PI4KIIα establishes the Golgi's unique lipid-defined organelle identity by generating PI (4)P-rich domains that specify the docking of the AP-1 coat …