The CtIP-CtBP1/2-HDAC1-AP1 transcriptional complex is required …
Apr 19, 2022 · In this study, we reveal that C-terminal binding protein (CtBP) interacting protein (CtIP) couples with three transcriptional regulators, CtBP1/2 heterodimer, histone deacetylase …
- DOI: 10.1016/j.tranon.2022.101429
- Published: 2022/07
- Publication: Transl Oncol. 2022 Jul; 21: 101429.
HDACs and the epigenetic plasticity of cancer cells: Target the ...
Oct 1, 2022 · HDAC2, together with HDAC3, can form a noncanonical complex with PACS-1 (phosphofurin acidic cluster sorting protein-1). PACS-1 is a well-known multifunctional …
Histone deacetylase (HDAC) 1 and 2 are Essential for normal T cell ...
Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways …
Overexpression of histone deacetylases in cancer cells is …
Jan 30, 2014 · We found that elevated HDAC1 and HDAC2 gene expression is regulated by transcription factors Sp1 and Sp3, as well as histone-modifying enzymes, such as H3K4 …
- Author: Hui Yang, Tal Salz, Maria Zajac-Kaye, Daiqing Liao, Suming Huang, Yi Qiu
- DOI: 10.1096/fj.14-250654
- Publish Year: 2014
- Publication: FASEB J. 2014 Oct; 28(10): 4265-4279.
AP-1 Mediated Transcriptional Repression of Matrix …
Aug 6, 2012 · We propose a model in which IFNβ leads to an increase in AP-1’s binding affinity for HDAC1 without a reduction in AP-1’s DNA binding capabilities. By specific recruitment of …
Functional domains of HDAC1/HDAC2 proteins.
Schematic view of the human HDAC1 and HDAC2 proteins as representatives for HDAC1-like and HDAC2-like proteins. Both share a highly conserved N-terminal part harbouring the HDAC association...
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The Regulatory Mechanisms of Tumor Suppressor P16
Lsh also physically interacts with the p16 promoter as well as histone deacetylases 1 and 2 (HDAC1 and HDAC2) in vivo, which consequently recruits a co-repressor complex containing HDAC1 and HDAC2 to the p16 promoter …
Role of HDACs in normal and malignant hematopoiesis
Jan 7, 2020 · HDAC1 and HDAC2 are essential regulators of HSC formation and homeostasis. Simultaneous deletion of HDAC1 and HDAC2 results in the loss of HSCs and, consequently, early hematopoietic progenitors, which are …
Histone hyperacetylation disrupts core gene regulatory …
Nov 29, 2019 · Hyperacetylation removes RNA polymerase II (RNA Pol II) from core regulatory genetic elements, and eliminates RNA Pol II but not BRD4 phase condensates. This study identifies an SE-specific...
Histone deacetylases 1 and 2 regulate the transcriptional …
Here, we report that NPC-specific deletion of Hdac1 and Hdac2 genes in mice results in early postnatal lethality owing to renal hypodysplasia and loss of NPCs. HDAC1/2 interact with the …
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