Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] . AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2] .

AP-1 is a dimeric transcription factor that contains members from the JUN, FOS, ATF and MAF protein families. AP-1 activity can be regulated by dimer composition, transcription,...

In this review, we will attempt to unravel the roles of AP-1 in the regulation of anti-tumor immune responses, with a focus on the regulation of immune checkpoints and Tregs, seeking to extract useful insights for more efficacious immunotherapy.

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death.

Mar 30, 2025 · FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOS include Histiocytoid Hemangioma and Congenital Generalized Lipodystrophy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

May 1, 2002 · AP-1 activity is induced by a plethora of physiological stimuli and environmental insults. In turn, AP-1 regulates a wide range of cellular processes, including cell proliferation, death,...

The transcription factor AP1 is a homomeric and heteromeric protein dimer between Jun and Fos family members with leucine-zipper motifs. The AP1 complex is able to recognize the core element TGACTCA on double stranded DNA and thereby modulate transcription into mRNA of particular target genes.

Dec 21, 2017 · AP-1 TFs are transcriptional effectors of growth factor/receptor tyrosine kinase (RTK) signaling and are activated by the Ras/MAPK pathway in nearly all cell types, raising the question of how they could contribute to cell-type-specific enhancer selection.

AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development.

Mar 23, 2021 · Although, members of the activator-protein-1 (AP-1) family, including Batf3, have been implicated in conventional (c)DC specification, the role of Jun proteins is poorly understood. Here, we...