Dec 15, 2016 · These data indicate a novel regulatory role of PKC to inhibit AMPKα1 in human cells. As PKC activation is associated with insulin resistance and obesity, PKC may underlie …

PKC activation was associated with reduced AMPK activity, as inhibition of PKC increased AMPK activity and phorbol esters inhibited AMPK, an effect lost in cells expressing mutant AMPKα1 …

Oct 21, 2023 · AMPK activity is lowered by AMPKα1 Ser487 phosphorylation stimulated by PKC isoforms. High glucose-induced PKC signaling is intensified by ROS, leading to PKC protein …

Feb 4, 2008 · In the present study, we have found that metformin activates AMPK by activating PKC-ζ–dependent LKB1 phosphorylation at Ser428, a site that is required for LKB1 nuclear …

Jun 4, 2015 · 5′AMP-activated protein kinase (AMPK) plays an essential role in the regulation of the cellular energy homeostasis as it inhibits energy consuming processes. AMPK is activated …

Sep 19, 2018 · These resulus demonstrated that simple inhibition of AMPK did not reduce ULK1 activation and mitophagy, the compensatory increase in PKC maintained ULK1 and mitophagy …

PKC can activate LKB1/AMPK, leading to phosphorylation and activation of Syk, and subsequent activation of Src and FAK. In addition, PKC-dependent ERK activation induces a coordinated …

This study examines the role of protein kinase C (PKC) and AMP-activated kinase (AMPK) in acetaminophen (APAP) hepatotoxicity. Treatment of primary mouse hepatocytes with broad …

Nov 1, 2013 · Using inhibitors, we define a stress-dependent pathway that requires the activity of the cellular energy sensor AMPK (AMP-activated protein kinase) and PKC (protein kinase C) …

Jun 15, 2017 · AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels. The …