Aug 10, 2024 · Our recent studies have identified p21-activated kinase 4 (PAK4) as a key regulator of lipid catabolism in the liver and adipose tissue, but its role in glucose homeostasis …

Jul 6, 2016 · A recent unbiased screen for α2 AMPK substrates identified p21-activated protein kinase (specifically the PAK2 isoform) (Banko et al., 2011), a known post-synaptic driver of …

For limited glucose (e.g., C g = 0.2 mM), AMPK is partially activated and p53 is further activated by AMPK p, with [AMPK p] and [p53 p] at low or intermediate levels (Figure 3A). p21 is …

Feb 23, 2017 · In this study, we demonstrated simvastatin-induced G0/G1 arrest by inducing p21 and p27 accumulation in HepG2 and Hep3B cells. Simvastatin also promoted AMP-activated …

Activation of AMPK reduced p21 protein and mRNA expression, which was associated with reduced G 1 /S cell cycle transition and p21 promoter activity. AICAR-treated myoblasts …

Jul 6, 2016 · AMP-activated protein kinase (AMPK) plays an important role in regulating food intake. The downstream AMPK substrates and neurobiological mechanisms responsible for …

AMP-activated protein kinase (AMPK) plays an important role in regulating food intake. The down-stream AMPK substrates and neurobiological mech-anisms responsible for this, however, are …

Jul 6, 2016 · Kong et al. employed neuron-specific approaches and established that fasting-stimulated AMPK activity in AgRP neurons is both necessary and sufficient for fasting-induced …

Sep 1, 2010 · We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21(waf/cip) and regulation of the cell cycle and …

Sep 8, 2020 · Further, AMPK activation plays a vital role in the regulation of the oxidative stress-induced G2 arrest through the inhibition of CDK1 activity via p53/p21 pathways, thereby …