Here, we found that AMP-activated protein kinase (AMPK) and CREB are oppositely regulated in mouse primary hippocampal neurons impaired by hypoxia-hypoglycemia. AMPK overexpression reduced the CREB level by upregulating SIRT1 and was negatively posttranscriptionally regulated by miR-134, suggesting a negative regulatory role of AMPK in the ...

Feb 1, 2008 · Since previous reports show a cAMP response element in the promoter region of the hexokinase II gene, we hypothesized that the cAMP-response element (CRE) binding protein (CREB) family of transcription factors could be targets of AMPK.

Jul 15, 2016 · In this review, we discuss the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition, we discuss the mechanisms...

Dec 1, 2022 · Metformin can activate AMPK-CREB and subsequent BDNF transcription, and also inhibit mTOR downstream autophagy. Metformin activates the AMPK-PKC-CBP pathway to stimulate neurogenesis in neurons, these processes indicate neurotrophic and neurogenesis-stimulated actions by metformin in the neuron.

AMPK anti-gluconeogenic effects are achieved through a combination of different transcriptional mechanisms. A constellation of transcriptional regulators modulates gluconeogenesis, such as CRTC2, FOXO, ChREBP, HNF4α and PGC-1α. AMPK impacts on …

Sep 2, 2020 · Mechanistically, low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway. Furthermore, high GLUT3 expression remarkably increased the sensitivity of CRC cells to...

Apr 6, 2021 · Inhibition of AMP-activated protein kinase (AMPK) abrogates the induction of CREB/ATF1 phosphorylation by aspirin. Mechanistically, activation of AMPK by aspirin results in decreased expression of the urea cycle enzyme carbamoyl-phosphate synthase 1 (CPS1) in HCC cells and xenografts.

AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming ...

Feb 17, 2011 · Here we show that both AMPK and calcineurin modulate longevity exclusively through post-translational modification of CRTC-1, the sole C. elegans CRTC. We demonstrate that CRTC-1 is a direct AMPK target, and interacts with the CREB homologue-1 (CRH-1) transcription factor in vivo.

Feb 3, 2015 · AMPK overexpression reduced the CREB level via upregulating SIRT1 and negative posttranscriptional regulation by miR-134, suggesting a negative regulatory role of AMPK in the expression of CREB. However, it was interesting that the downstream genes, BDNF and Bcl-2, remained unchanged.