Apr 5, 2010 · We show that the Bcl-2 homology domain 3 (BH3)–only protein Bim, a proapoptotic Bcl-2 family member, is activated in multiple excitotoxicity paradigms, mediates excitotoxic …

Apr 27, 2012 · We have previously shown that ATP depletion and activation of AMP-activated protein kinase (AMPK) during excitotoxic injury induces neuronal apoptosis by transcription of …

AMPK, a highly conserved serine/threonine protein kinase, serves as a master sensor and regulator of energy balance and controls many cellular processes, such as autophagy, cell …

We recently reported that AMP-activated protein kinase (AMPK) contributes to zinc-induced neuronal death by inducing Bim, a pro-apoptotic Bcl-2 homology domain 3-only protein, in a …

Mechanistically, direct binding of penfluridol and PFKL inhibits glucose consumption, lactate and ATP production, leads to nuclear translocation of FOXO3a and subsequent transcriptional …

In the present study, we demonstrate that Ang II activation of AMPK leads to transcriptional regulation of the proapoptotic BH3-only protein Bim in PAEC. Ang II-induced phosphorylation …

Feb 6, 2019 · Pharmacological activation of AMPK enhances the BIM load in MYC-overexpressing cells (red arrow), which together with inhibition of BCL-2/X L triggers apoptosis.

Apr 5, 2010 · In this study, we demonstrate that even a transient decrease in cellular bioenergetics and an associated activation of adenosine monophosphate-activated protein …

pro-longed AMPK activation is sufficient to induce bim gene expression and to trigger a bim-dependent cell death. Collectively, our data demonstrate that A. PK activation and the BH3 …

Activation of caspase-3 is induced by liver kinase B1 (LKB1)-AMP-activated kinase (AMPK)-Bim cascade signaling and induction of p75NTR receptors and p75NTR-associated Death …