Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN ...
Recent studies have revealed how AMPK is activated inside the cell and animal tissues: in response to low glucose, AXIN tethers LKB1, by virtue of their constitutive association, to …
AXIN-AMPK signaling: Implications for healthy aging - PMC
The energy sensor AMP kinase (AMPK) and the master scaffolding protein, AXIN, are two major regulators of biological processes in metazoans. AXIN-dependent regulation of AMPK …
The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK ...
Sep 2, 2014 · Under glucose starvation, the v-ATPase-Ragulator complex is accessible to AXIN/LKB1 for AMPK activation. Concurrently, the guanine nucleotide exchange factor (GEF) …
AMPK: Sensing Glucose as well as Cellular Energy Status
Feb 6, 2018 · Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. We review recent information about how this …
AXIN-AMPK signaling: Implications for healthy aging
Dec 8, 2021 · AXIN-dependent regulation of AMPK activation plays a crucial role in maintaining metabolic homeostasis during glucose-deprived and energy-stressed conditions. The two …
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK ...
Sep 2, 2014 · Under glucose starvation, the v-ATPase-Ragulator complex is accessible to AXIN/LKB1 for AMPK activation. Concurrently, the guanine nucleotide exchange factor (GEF) …
Hierarchical activation of compartmentalized pools of AMPK …
Apr 4, 2019 · Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting …
AMPK hierarchy: a matter of space and time - PMC
AMP-activated protein kinase (AMPK) is a key sensor of energy balance in eukaryotic cells, responding to low energy status by switching off anabolic pathways and upregulating catabolic …
AMPK hierarchy: a matter of space and time - PMC - National …
Apr 25, 2019 · AMP-activated protein kinase (AMPK) is a key sensor of energy balance in eukaryotic cells, responding to low energy status by switching off anabolic pathways and …
AMPK hierarchy: a matter of space and time | Cell Research
Apr 25, 2019 · AMP-activated protein kinase (AMPK) is a key sensor of energy balance in eukaryotic cells, responding to low energy status by switching off anabolic pathways and …