AML1/ETO and its function as a regulator of gene transcription …
Jul 30, 2021 · In this review, we describe the wide-ranging role of AML1/ETO in AML leukemogenesis, with a particular focus on the aberrant epigenetic regulation of gene …
Oncogenic pathways of AML1-ETO in acute myeloid leukemia: …
AML1-ETO, through its rhd, retains the ability to bind RUNX1 DNA binding sites and through the ETO moiety gains the capacity to recruit additional cofactors, mostly corepressors. Thus AML1 …
RUNX1-ETO Leukemia - PubMed
AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the …
AML1-ETO expression is directly involved in the development of …
AML1-ETO is specifically expressed in myeloid cells, including common myeloid progenitors of hMRP8-AML1-ETO transgenic mice. The transgenic mice were healthy during their life spans, …
AML1/ETO accelerates cell migration and impairs cell-to-cell …
Oct 7, 2016 · Our results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the …
AML1 and the AML1-ETO fusion protein in the pathogenesis of …
Oct 8, 2001 · In this overview the roles of the AML1 and ETO proteins will be reviewed individually. The way in which the function of AML1 might be subverted by the leukemogenic …
Definition of a small core transcriptional circuit regulated by AML1-ETO
Feb 4, 2021 · Stengel et al. combine PROTAC-mediated degradation of the oncogenic transcription factor AML1-ETO with nascent transcript analysis to identify direct gene targets. …
Definition of a small core transcriptional circuit regulated by AML1-ETO
Feb 4, 2021 · The rapid kinetics of AML1-ETO removal, when combined with analysis of transcriptional output by nascent transcript analysis and genome-wide AML1-ETO binding by …
AML1/ETO and its function as a regulator of gene transcription …
In this review, we describe the wide-ranging role of AML1/ETO in AML leukemogenesis, with a particular focus on the aberrant epigenetic regulation of gene transcription driven by this AML …
AML1/ETO and its function as a regulator of gene transcription …
In this review, we describe the wide-ranging role of AML1/ETO in AML leukemogenesis, with a particular focus on the aberrant epigenetic regulation of gene transcription driven by this AML …
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