Murine Models of Acute Myeloid Leukaemia - PMC
Here we review the most important AML mouse models of each category, briefly describe their advantages and limitations and show how they have contributed to our understanding of the …
A robust and rapid xenograft model to assess efficacy …
Mar 20, 2015 · Relevant preclinical mouse models are crucial to screen new therapeutic agents for acute myeloid leukemia (AML). Current in vivo models …
- Author: E Saland, H Boutzen, R Castellano, L Pouyet, E Griessinger, C Larrue, F de Toni, S Scotland, Mathieu...
- Publish Year: 2015
Patient-Derived Acute Myeloid Leukemia (AML) Models
Robust engraftment of the primary AML samples in NSG™-SGM3 mice has been confirmed. This multi-allelic strain combines an immunodeficient environment with the expression of three transgenic human cytokines (SCF, GM-CSF, & IL-3) …
- Studies of AML Mouse
Murine Models of Acute Myeloid Leukemia - PMC
Virally-induced mouse models of AML led to important discoveries of previously unknown oncogenes and the underlying pathogenesis of leukemia (32–34). Gene editing has recently …
The Impact of the Cellular Origin in Acute Myeloid Leukemia: …
Mouse models functionally classify AML-associated mutations. “TYPE-A mutations” initiate and/or maintain a leukemic phenotype in the mouse. Targeted inactivation might have the potential to …
An Advanced Preclinical Mouse Model for Acute Myeloid …
Mar 20, 2015 · In the present work, we developed the individualized xenograft mouse model of AML further by evaluating serial transplantation and introducing lentiviral transduction and …
- Author: Binje Vick, Maja Rothenberg, Nadine Sandhöfer, Michela Carlet, Cornelia Finkenzeller, Christina Krup...
- Publish Year: 2015
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Mouse models of NPM1 -mutated acute myeloid leukemia
Sep 2, 2014 · In this review, we provide a synopsis of three types of mouse models (xenotransplant, transgenic and knock-in) that are currently available to understand NPM1- …
New research finds novel drug target for acute myeloid …
Mar 26, 2025 · An aggressive blood cancer, AML originates in the bone marrow and is known to disrupt the normal production of blood cells. Treatment is difficult because patients may not respond to chemotherapy or experience a relapse …
Identification of CD84 as a potent survival factor in acute myeloid ...
Apr 8, 2025 · Critically, loss of CD84 also markedly blocked leukemia engraftment and clonogenicity in MLL-AF9 and inv(16) AML mouse models, highlighting its pivotal role as …
Perturbing LSD1 and WNT rewires transcription to ... - Nature
1 day ago · a, Mouse AML cells treated with 50 nM GSK–LSD1 and different concentrations of LY2090314 for 5 days; cell growth was determined by the Cell-Titer-Glo assay. Data are …
