ALDH2 is a tetrameric enzyme that contains three domains; two dinucleotide-binding domains and a three-stranded beta-sheet domain. The active site of ALDH2 is divided into two halves by the nicotinamide ring of nicotinamide adenine dinucleotide (NAD +).

Jan 25, 2023 · Around 8 per cent of the world’s population has a gene variant called ALDH2*2 that impairs the body’s ability to metabolise alcohol and causes unpleasant symptoms such as flushing soon after...

Summary: The alcohol flushing-associated ALDH2*2 variant is one of the most common genetic polymorphisms in humans. This variant exhibits complex pleiotropic effects associated with alcohol consumption and aldehyde toxicity, which diversely impact human health.

Feb 13, 2023 · In this Review, we summarize the basic biology and the clinical relevance of the enzymatic and non-enzymatic, tissue-specific roles of ALDH2 in CVD, and discuss the future directions in the...

Aug 14, 2024 · ALDH2 deficiency refers to a deficiency in a detoxifying enzyme that makes it harder for the liver to break down some toxins that enter the body. The typical human liver contains two major aldehyde dehydrogenase enzymes, a cytosolic ALDH1 component, and a mitochondrial ALDH2 component.

In addition to the well-characterized inhibitors of ALDH2, new research tools, including more selective inhibitors, transgenic mice with altered ALDH2 activity, and selective ALDH2 activators have shed new light on the role of ALDH2 in human diseases.

Sep 9, 2019 · ALDH2 deficiency, more commonly known as Alcohol Flushing Syndrome or Asian Glow, is a genetic condition that interferes with the metabolism of alcohol. As a result, people with ALDH2 deficiency have increased risks of developing esophageal and head & neck cancers .

Feb 8, 2025 · ALDH2: Essential Mediator for the Remote Ischemic Conditioning Strategy to Reduce Myocardial Ischemia/Reperfusion Injury. ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma. ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.

ALDH2 is a mitochondrial enzyme found in the liver and mucosa of the upper intestinal tract, among other tissues, and is primarily responsible for the oxidation of simple aldehydes such as acetaldehyde, which, as stated earlier, is a potential carcinogen.

Aldehyde dehydrogenase 2 (ALDH2) is one of the aldehyde dehydrogenase family of enzymes. As another member of the aldehyde dehydrogenase family, ALDH1 is widely known for its key role in carcinogenesis and cancer treatment (1).