Apoptosis Inducing Factor (AIF) is a protein that triggers chromatin condensation and DNA fragmentation in a cell in order to induce programmed cell death. The mitochondrial AIF protein was found to be a caspase -independent death effector that can allow independent nuclei to undergo apoptotic changes.

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-dependent oxidoreductase residing in the mitochondrial intermembrane space whose specific enzymatic activity remains unknown.

Apoptosis-inducing factor (AIF) is a nuclear encoded mitochondrial inter-membrane space flavoprotein, regarded as an apoptotic effector molecule. AIF is encoded by the AIFM1 gene which has a total length of 36,525 bases and is located in the Xq26.1 region, with 17 exons and four variable shears (1).

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large number of studies have elucidated AIF's participation to chromatin condensation during cell ...

Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase that contributes to cell death programmes and participates in the assembly of the respiratory chain. Importantly, AIF deficiency leads to severe mitochondrial dysfunction, causing muscle atrophy and neurodegeneration in model organisms as well as in humans.

Mar 12, 2004 · Apoptosis-inducing factor (AIF) is a mitochondrion-localized flavoprotein with NADH oxidase activity that is encoded by a nuclear gene. 1, 2, 3 AIF has been shown to translocate from...

Apoptosis-inducing factor (AIF) is a phylogenetically ancient mitochondrial intermembrane flavoprotein endowed with the unique capacity to induce caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation when added to purified nuclei.

The apoptosis-inducing factor (AIF) is a mitochondrial protein with a double function: it mediates programmed cell death, independently from the activation of caspases, but it is also a NADH-dependent oxidoreductase with an essential role in bioenergetic metabolism.

Jun 15, 2011 · Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-dependent oxidoreductase residing in the mitochondrial intermembrane space whose specific enzymatic activity remains unknown.

Jul 7, 2000 · Apoptosis-inducing factor (AIF) is encoded by one single gene located on the X chromosome. AIF is ubiquitously expressed, both in normal tissues and in a variety of cancer cell lines. The AIF precursor is synthesized in the cytosol and is imported into mitochondria.