ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. [1] 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. [2]

Aug 30, 2018 · ADAMTS13 deficiency is the cause of TTP but also has a significant role in the pathophysiology, diagnosis, and prognosis of other TMAs and thrombotic disorders, such as stroke and myocardial infarction.

May 30, 2015 · The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology.

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc -containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a …

ADAMTS-13 is a Zn 2+ - and Ca 2+-requiring 190,000-dalton glycosylated protein that is encoded on chromosome 9q34 and produced predominantly in the liver.

The ADAMTS superfamily comprises an important group of extracellular matrix modifying proteases and non-structural proteins. ADAMTS gene mutations lead to diverse genetic disorders and ADAMTS variants are associated with several complex acquired diseases.

With at least nine members in mammals alone, the ADAMTS family members are predicted by their structural domains to be extracellular matrix (ECM) proteins with a wide range of activities and functions distinct from members of the ADAM family that are …

The ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body ...

ADAMTS proteins have numerous potential connections to other human disorders that were identified by genome-wide association studies. Here, we review inherited and acquired human disorders in which ADAMTS proteins participate, and discuss progress and prospects in …

Dec 9, 2023 · This review focuses on the roles of ADAM and ADAMTS proteinases in diseases with pathological tissue remodeling, with particular emphasis on the molecular mechanisms through which ADAM and...