Here, we report the results of silencing a disintegrin and metalloprotease 17 (ADAM17) in cultured rat vascular smooth muscle cells and its functional mechanism in angiotensin II signal transduction. 3 distinct mi/siRNA sequences targeting rat ADAM17 were inserted into pAd/CMV/V5-DEST and adenoviral solutions were obtained.

Aug 1, 2022 · In this study, we created cardiomyocyte-specific knockout of ADAM17 (A17 α-MHCKO) mice, and left ventricular dimension, function, pathology and molecular biology were assessed in ADAM17 fl/fl...

We showed in a previous study that silencing of ADAM17 by siRNA inhibited the growth of MCF-7 breast cancer cells in vitro and in vivo. In the present study, we investigated the effects of ADAM17-short hairpin RNA (ADAM17-shRNA) on MCF-7 breast cancer cells and explored the potential action pathway.

Search all TaqMan™ Assays for mRNA and long noncoding RNA analysis, including endogenous control and marker/reporter gene products. 41 ADAM17 Silencer Select Pre-designed, …

Here we describe isolation of primary human monocytes from peripheral blood and their in vitro differentiation to macrophages, followed by electroporation with siRNA to silence expression of a disintegrin and metalloproteinase 17 (ADAM17).

Here, we report that treating human HNSCC cells in vitro with a human anti-ADAM17 inhibitory antibody, D1 (A12), suppresses proliferation and motility in the absence or presence of the EGFR tyrosine kinase inhibitor (TKI) gefitinib.

A disintegrin and metalloprotease 17 (ADAM17) is highly expressed in many malignant tumors and is closely related to their development. We showed in a previous study that silencing of ADAM17 by siRNA inhibited the growth of MCF‑7 breast cancer cells in vitro and in vivo.

Here, we report the results of silencing a disintegrin and metalloprotease 17 (ADAM17) in cultured rat vascular smooth muscle cells and its functional mechanism in angiotensin II signal transduction. 3 distinct mi/siRNA sequences targeting rat ADAM17 were inserted into pAd/CMV/V5-DEST and adenoviral solutions were obtained.

Aug 1, 2016 · ADAM17 Antibody, a Small Molecule ADAM17 Inhibitor or Adenovirus Encoding ADAM17 siRNA, Attenuates a Fibrotic Response Induced by AngII In Vitro To test for the role of ADAM17 in AngII-induced vascular fibrosis, extracellular collagen content was evaluated in VSMCs stimulated with AngII.

Intravitreous injection of siRNA either for ADAM12 or ADAM17 rescues the retinal vasculature from the hypoxia-induced decrease in claudin-5 expression, in contrast to the hypoxic vasculature with the injection of non-silencing siRNA (NC siRNA).