May 21, 2024 · ADAM17 (p.D647N) mutation led to hair follicle stem cell (HFSC) exhaustion and caused abnormal hair follicles, ultimately resulting in alopecia. Mechanistic studies revealed …

ADAM17 (p.D647N) mutation led to hair follicle stem cells (HFSCs) exhaustion and caused abnormal hair follicles, ultimately resulting in alopecia. Mechanistic studies revealed that …

May 6, 2022 · TRIM47-deficient mice were effectively resistant to lipopolysaccharide (LPS)-induced acute lung injury and death by attenuating pulmonary inflammation. TRIM47 was …

An Adam17-knockin mouse model mimicked the hair abnormality in patients. We discovered that TRIM47, an E3 ubiquitin ligase, interacted with the mutant ADAM17, promoting its …

Mar 11, 2023 · In the current study, we shown that overexpression of TRIM47 correlates with progression and poor prognosis in triple-negative breast cancer.

May 21, 2024 · Mechanistic studies revealed that ADAM17 binds directly to E3 ubiquitin ligase tripartite motif-containing protein 47 (TRIM47). ADAM17 variant enhanced the association …

326 enhanced the interaction between ADAM17 and its E3 ubiquitin ligase TRIM47, 327 leading to increased auto-ubiquitination and consequent degradation of ADAM17.

May 21, 2024 · TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2 Article

Supplementary Materials for ADAM17 variant causes hair loss via ubiquitin ligase TRIM47 mediated degradation.

May 21, 2024 · ADAM17 (p.D647N) mutation led to hair follicle stem cells (HFSCs) exhaustion and caused abnormal hair follicles, ultimately resulting in alopecia. Mechanistic studies …