A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of …

ADAM17 plays a key role in activating IL-6 trans-signaling pathway, as it sheds the ectodomain of IL-6R, both in vitro and in vivo [27,28]. Soluble IL-6R (sIL-6R) retains its ability to bind IL-6, …

Nov 13, 2024 · The functional ADAM17 is involved in the shedding of the ectodomain characterizing many substrates belonging to growth factors, cytokines, receptors, and …

Oct 12, 2016 · ADAM17 is mainly endocytosed via a clathrin-dependent pathway. Which endocytic pathway is responsible for ADAM17 internalisation?

This review provides an overview of the role of ADAM17 in EMT-associated pathways, highlighting new therapeutic perspectives on fibrotic diseases and cancer. As this review …

Aug 4, 2023 · ADAM17 is involved in the cleavage and shedding of at least 80 known membrane-tethered proteins, which subsequently modulate several intracellular signaling pathways, and …

Knowledge of the substrates of ADAM17 helped provide a pathway as to what would be the best use of an ADAM17 inhibitor in the clinic. Researchers have now developed selective inhibitors …

Aug 1, 2011 · Activated ADAM17 is capable of controlling pathways that are biologically distinct. On one hand, cleavage of substrates, including TNFα, IL-6R and L-selectin, can be …

Feb 10, 2021 · Neuron-associated ADAM17 may have a beneficial effect by triggering the non-amyloidogenic pathway of APP processing, while microglia-associated ADAM17 can be …

Dec 18, 2024 · The functional ADAM17 is involved in the shedding of the ectodomain characterizing many substrates belonging to growth factors, cytokines, receptors, and …