ADAM17 TDP has shown to efficiently inhibit ADAM17 functions in vivo. ADAM17, via shedding of TGFα and activation of EGFR, plays a negative role in neuronal regeneration after brain …

Sep 22, 2022 · We identified ADAM17, a sheddase upregulated in many cancer types, as a protein of interest. Depletion of ADAM17 in cancer cell lines reduced the expression of several …

Mar 12, 2018 · We find that ADAM17 deficiency in the skin of Rhbdf2 cub mice restores a full hair coat, prevents sebaceous gland enlargement, and impairs the rapid wound‐healing phenotype …

ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand …

Jul 13, 2011 · ADAM17 modulates inflammation by activation of TNFR- and IL-6R-mediated signal transduction. Therefore, ADAM17 activation is considered a pro-inflammatory event. …

Therefore, targeting ADAM17 to reduce soluble ligand levels would increase cellular immune responses to tumor cells. Fc γ RIIIA or CD16 is a low-affinity receptor for the IgG expressed on …

ADAM17 overexpression elevates the expression of MMP-2 and MMP-9, while ADAM17 knockdown downregulates the expression of the same MMPs. This evidence clearly suggests …

Aug 23, 2022 · Together, our findings identify ADAM17-mediated EGFR ligand shedding as a potentially novel molecular mechanism, used by cancer cells to manipulate and hijack …

Jun 4, 2012 · ADAM17 regulates the skin barrier by controlling EGFR ligand shedding and EGFR signaling in keratinocytes, as indicated by lack of TGF-α shedding from A17 ΔKC …

Nov 13, 2024 · ADAM17 is a member of the disintegrin and metalloproteinase (ADAM) family of transmembrane proteases with immunoregulatory activity in multiple signaling pathways. The …