A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. [5] Members of the ADAM family are cell surface proteins with a unique structure, possessing both potential adhesion and protease domains.

Mar 30, 2025 · ADAM10 (ADAM Metallopeptidase Domain 10) is a Protein Coding gene. Diseases associated with ADAM10 include Reticulate Acropigmentation Of Kitamura and Alzheimer Disease 18. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been identified as the constitutive α-secretase in the process of amyloid-β protein precursor (AβPP) cleavage and plays a critical role in reducing the generation of the amyloid-β (Aβ) peptides.

Feb 8, 2025 · ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion. ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis. Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.

Several ADAM10 inhibitors proved to be effective in reducing tumor cell growth, inducing anti-tumor immune reactions or enhancing the effect of therapeutic antibody-drug conjugates in vitro. Examples are given by studies in gliomas, solid cancers, and hematologic tumors, including Hodgkin lymphoma (14, 20–24).

We will discuss some examples of ADAM10 activity modulated by changing partners and subcellular compartmentalization, with the underlying hypothesis that restraining protease activity by spatial segregation is a complex and powerful regulatory tool.

Sep 21, 2018 · This study shows that ADAM10 is the receptor for the staphylococcal toxin α-haemolysin in vivo and identifies ADAM10 activity as a novel therapeutic target for α-haemolysin-induced disease.

Mar 24, 2020 · Generating inhibitors for A Disintegrin And Metalloproteinase 10 (ADAM10), a zinc-dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 years ago.

Human ADAM10 is localized on chromosome 15 (15q22) and is widely expressed in mammalian organs, including brain. The role of ADAM10 as α-secretase cleaving APP has been confirmed by overexpression in intact cells, which leads to a several-fold increase in …

Jan 1, 2024 · Studies have shown that A Disintegrin and Metalloproteinase 10 (ADAM10) is the main α-secretase in the non-amyloidogenic cleavage of the amyloid precursor protein (APP), avoiding the production of amyloid-β peptide (Aβ), one of the pathological hallmarks of Alzheimer's disease (AD).