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Dec 22, 2016 · Here we demonstrate that ADAM17-dependent EGFR signalling promotes TG activity in keratinocytes committed to terminal differentiation by direct induction of TG1 …

Here, we demonstrate that the membrane-anchored metalloproteinase ADAM17, but not ADAM10, is the sheddase that rapidly responds to the physiological signaling pathways …

Description: Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), transcript variant 1, mRNA. (from RefSeq NM_003183) RefSeq Summary (NM_003183): This gene encodes a …

Jun 4, 2012 · We show that mice lacking ADAM17 in keratinocytes (A17ΔKC) have a normal epidermal barrier and skin architecture at birth but develop pronounced defects in epidermal …

Nov 1, 2017 · Using both pharmacological and genetic approaches we report that the main protease contributing to the release of TREM2 ectodomain is ADAM17, (a disintegrin and …

Jun 1, 2021 · FUS treatment increased the uptake of 68 Ga-DOTA-ECL1i and 64 Cu-CuNCs to the DIPG tumor by 3.25 folds and 4.07 folds on average, respectively. These findings …

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Dec 22, 2016 · Our results suggest ADAM17/EGFR-driven PLCγ1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation. These …

Jul 1, 2010 · Mechanistically, we found that ADAM-17 not only regulated phosphorylation of HERs, but also increased the activity of a number of other growth factor receptors, such as …