Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is …

Dec 8, 2023 · Antibodies against the chemokine platelet factor 4 (PF4) occur often, but only those that activate platelets induce severe prothrombotic disorders with associated thrombocytopenia.

Dec 10, 2011 · Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4)/polyanion complexes.

This ELISA assay detects the presence of IgG antibodies to heparin-platelet factor 4 (PF4) complexes. Most cases of heparin-induced thrombocytopenia (HIT) are caused by IgG …

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be …

Dec 8, 2020 · Heparin-induced thrombocytopenia (HIT) is a complication of treatment with heparin caused by antibodies. A test for HIT (heparin-PF4) antibody helps diagnosis HIT type II.

Heparin is a commonly used anticoagulant in various clinical settings, and can be given either intravenously or subcutaneously. In HIT, heparin interacts with PF4, a small cytokine …

Nov 5, 2024 · Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin therapy, driven by IgG antibodies (Abs) that target platelet factor 4 (PF4) bound to heparin, …

Mar 1, 2025 · Presently, only platelet activation assays reliably distinguish anti-PF4/H Abs that cause disease (HIT Abs) from those likely to be asymptomatic (AAbs). Recent studies indicate …

Dec 12, 2018 · Anti-PF4/H Abs are classified into three groups: (i) nonpathogenic Abs (group 1) with no clinical relevance; (ii) pathogenic heparin-dependent Abs (group 2), which activate …