ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is …

Pancreatic β-cell specific Abca1 KO mice (Abca1-P/-P) showed age-related and gene-dose-dependent accumulation of cholesterol in β-cells. In addition, these mice showed significantly …

Mar 28, 2025 · ABCA1 (ATP Binding Cassette Subfamily A Member 1) is a Protein Coding gene. Diseases associated with ABCA1 include Tangier Disease and Hypoalphalipoproteinemia, …

ABCA1 functions as a lipid transporter because it mediates the transfer of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins present in the …

The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. …

ABCA1 exports cholesterol and phospholipids from cells by multiple steps that involve forming cell surface lipid domains, binding of apolipoproteins to ABCA1, activating signaling pathways, and …

Aug 16, 2022 · ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density …

ABCA1 acts as a cholesterol pump, removing cholesterol from the cell's interior. Variants in this gene play a role in heart and eye health.

Jul 23, 2024 · ABCA1 transporter promotes the motility of human melanoma cells by modulating their plasma membrane organization. Wu A, Mazurkiewicz E, Donizy P, Kotowski K, Pieniazek …

Jan 1, 2002 · ATP-binding cassette transporter-1 (ABCA1) mediates the lipid efflux from cells to apolipoproteins. In studying the gene expression and regulation of ABCA1 in human vascular …