Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called α (alpha) and β (beta) TCR chains.

This chapter will summarize our current understanding of how distinct TCR signals drive an uncommitted progenitor to adopt the alternate αβ or γδ lineages, as well as how those TCR signals influence γδ effector fates.

The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

Aug 20, 2010 · We present recent evidence that supports a 'TCR signal strength' model in which quantitatively larger TCR-mediated signals are proposed to favour γδ T cell lineage development.

Jan 26, 2015 · Here, we summarize the current knowledge on the formation of the TCR repertoire and its maintenance in health and disease. We also outline the various molecular mechanisms that govern the...

Mar 28, 2019 · In this review, we will discuss the current state of knowledge of the molecular mechanism of TCR signal transduction and its role in the thymic development of γδT cells, particularly highlighting a newly discovered mechanism that …

Both αβ and γδ T cells develop in the thymus from a common progenitor. Historically distinguished by their T-cell receptor (TCR), these lineages are now defined on the basis of distinct molecular programs.

Apr 26, 2018 · In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of antigen-presenting cells.

Aug 12, 2005 · The TCR is a genetically recombined receptor, analogous to an antibody, that is composed of two chains, either α and β in αβ T cells or γ and δ in γδ T cells. The binding site of the TCR is comprised of six loops called complementarity determining regions (CDRs), with each chain contributing three loops, called CDR1, 2, and 3 (Figure 1B ...