Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae.

Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to target cells, and has attracted a significant amount of attention in the field, especially in clinical-stage experimental therapeutic strategies.

Learn about the types of plasmids used to produce AAV in the lab. Addgene’s AAV Guide will teach you about AAV components, serotypes, pseudotyping, and more.

Apr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...

Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to the growth of the gene therapy field.

Jan 14, 2022 · Viral vectors have taken the center stage in gene therapy applications due to their evolutionarily fine-tuned ability to infect host tissue/cells [3]. Adeno-associated virus (AAV) [4] based...

Feb 1, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable...

Oct 31, 2022 · In this study, we reflect on the main basic aspects of AAV biology and provide an overview of the studies exploring the impact of AAV infection on human health, focusing on three major research areas including, (i) cervical and (ii) liver …

Feb 4, 2016 · We characterize AAVR as a protein capable of rapid endocytosis from the plasma membrane and trafficking to the trans-Golgi network. We show that AAVR directly binds to AAV2 particles, and that anti-AAVR antibodies efficiently block AAV2 infection.

Adeno-associated virus gets its name because it is often found in cells that are simultaneously infected with adenovirus. AAV are Parvoviridae: icosahedral, 20-25 nm in diameter; single stranded DNA genome with a protein capsid.