Using the basic principles of molecular biology and laboratory techniques presented in this chapter, researchers should be able to create a wide variety of AAV vectors for both clinical …

Adeno-associated virus (AAV) is a versatile viral vector technology that can be engineered for very specific functionality in gene therapy applications. To date, AAV has been shown to be …

Rational design approaches to capsid engineering leverage current scientific knowledge of AAV to further modulate, enhance and optimize the performance of the vectors. Capsid modification …

Learn about the types of plasmids used to produce AAV in the lab. Addgene’s AAV Guide will teach you about AAV components, serotypes, pseudotyping, and more.

Apr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in …

Feb 10, 2020 · In this Review, we discuss how AAV vectors can be genetically engineered to enhance their transduction and production and to overcome immunity barriers in patients. …

4 days ago · Adeno-Associated Virus (AAV) has become a pivotal tool in gene therapy, providing a safe and efficient platform for long-term transgene expression. ... We examine the molecular …

Sep 1, 2018 · Rational design of AAV relies on virus sequence, structure, and function knowledge. Strategies include point mutations, motif insertions, and chemical biology methods. Goals are …

Driven by the high clinical potential, a new generation of synthetic‐biologically engineered AAV vectors is on the rise. Concepts from synthetic biology enable the control and fine‐tuning of …

Jan 1, 2011 · Using the basic principles of molecular biology and laboratory techniques presented in this chapter, researchers should be able to create a wide variety of AAV vectors for both …