Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae.

Apr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...

These structures complete the structural atlas of the AAV serotype capsids. AAV7 represents the first clade D capsid structure; AAV11 and AAV12 are of a currently unassigned clade that would include AAV4; and AAV13 represents the first AAV2-AAV3 hybrid clade C capsid structure.

The AAV capsid encloses a 4.7-kb ssDNA genome, consisting of three open-reading frames: rep, cap and aap. The cap gene expresses three structural proteins (VP1, VP2 and VP3) that interact to form the capsid. AAV capsid attachment to cellular receptors plays a role in tissue tropism.

Jan 1, 2022 · The capsid structures of the AAV serotypes, AAV1-13 have been determined by either X-ray crystallography and/or cryo-electron microscopy (cryo-EM) (Large et al., 2021). The AAV capsids are assembled from sixty VPs through 2-, 3-, and 5-fold VP interactions.

Jan 13, 2021 · These structures complete the structural atlas of the AAV serotype capsids. AAV7 represents the first clade D capsid structure; AAV11 and AAV12 are of a currently unassigned clade that would include AAV4; and AAV13 represents the first AAV2-AAV3 hybrid clade C …

The structure of the AAV capsid is crucial for the virus’s ability to deliver its genetic material, interact with host cells, and evade the immune system. The capsid consists of 60 protein subunits arranged in a 20-sided icosahedral shape with a diameter of about 25 nanometers.

AAV capsid: A protein shell made from three related proteins—VP1, VP2, and VP3—that form a symmetrical icosahedral shape. These proteins, produced from a single gene region, assemble in a typical ratio of 1:1:10, providing the stability and protection needed to deliver the genome to target cells. The capsid’s compact and robust design ...

Dec 25, 2024 · Learn about Adeno-Associated Virus (AAV), its structure, life cycle, and applications in gene therapy. Explore how rAAV vectors are revolutionizing genetic medicine. Sample Submission Guidelines

Sep 7, 2023 · Otsuka Pharmaceutical has inked a collaboration that will use Shape Therapeutics' artificial intelligence (AI)-driven AAVid capsid discovery platform to develop intravitreally-delivered adeno-associated viruses (AAVs) to treat serious ocular diseases.