A66 is a potent inhibitor of the wild-type and oncogenic forms of p110α but not other class-I PI3K isoforms. The p110α-specific inhibitor A66 (0.7 μM) induces a 75-80% reduction in focus …

A66 is a potent and selective PI 3-kinase p110 α inhibitor (IC 50 = 32 nM). Exhibits >100-fold selectivity for p110 α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth …

Sep 14, 2015 · A66 derived from a pan-PI3K inhibitor PIK-93 has emerged as one of the most specific PI3Kα inhibitors with a similar potency against wild type PI3Kα, E545K and H1047R …

A66 is a potent and selective PI 3-kinase p110 α inhibitor (IC 50 = 32 nM). Exhibits >100-fold selectivity for p110 α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth …

A66 is a potent and selective p110α inhibitor with IC50 of 32 nM. P110α is the catalytic subunit of a class I Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic that is composed of a 85 …

A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α with an IC 50 of 32 nM and >100 fold selectivity for p110α over other class-I …

Potent and specific PI3K p110α inhibitor (IC50: 32 nM); highly selective for p110α over other PI3Ks and having a high degree of specificity as it does not target other protein kinases tested; …

A66 is an inhibitor of p110α PI3K that exhibits anticancer chemotherapeutic activity. A66 decreases cell viability of endometrial cancer cells and inhibits tumor growth of xenografts …