The present study was designed to investigate the effect of dicentrine on the enhancement of TNF-α-induced A549 lung adenocarcinoma cell death and to investigate the role of dicentrine as a potent inhibitor of TNF-α-induced cell invasion.

Our results suggest that the TNF-α-induced secretion of CXCL8 in A549 cells is regulated by the release of ACh, the latter's binding to the M3R and the downstream activation of NF-κB and the ERK1/2 and p38 MAPK signaling pathways.

Myricetin, an enhancer of SIRT1, inhibited TNF-α-induced NF-κB activation in A549 cells, therefore, reducing their inflammatory response. Our findings provide insight for novel therapies for inflammation-related diseases, such as asthma and chronic obstructive pulmonary disease.

Pyrazole downregulated the TNF-α mRNA and protein expression at definite time points in A549 cells which is probably one of the inflammatory and signaling pathway mediators that trigger EMT and promotes tumor metastasis.

Aug 19, 1997 · These studies show that inhibition of proteasome-mediated IκB degradation results in inhibition of TNF-α induced IL-8 production in A549 cells by limiting NF-κB-mediated gene transcription.

Nov 13, 2019 · Taken together, our results suggest that dicentrine could enhance TNF-α-induced A549 cell death by inducing apoptosis and reducing cell invasion due to, at least in part, the suppression of TAK-1, MAPK, Akt, AP-1, and NF-κB signaling pathways.

Jul 1, 2020 · In the present study, A549 cells were treated with TGF-β2 and TNF-α to induce EMT. Using microarray analysis, we investigated the effect of nintedanib on the global gene expression in A549 cells. Further, we examined the TGF-β/Smad pathway and analyzed the phosphorylation of Smad2/3.

Apr 20, 2008 · In this study, we show that tumor TNF-α induces monocyte adhesion to A549 human lung airway epithelium and also up-regulation of ICAM-1 expression. These effects were significantly diminished by...

Feb 14, 2018 · Sotetsuflavone can inhibit epithelial interstitial transformation, invasion, and metastasis of lung cancer cells in A549 cells through both PI3K/AKT and TNF-α/NF-κB pathways.

Dec 1, 2020 · Myricetin can reduce TNF-α-induced pro-inflammatory responses in A549 cells, partly through up-regulation of SIRT1 activity with post-translational modifications.