A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male. [1]

A549 cells were isolated from the lung tissue of a White, 58-year-old male with lung cancer. This cell line can be used in cancer, immuno-oncology, and toxicology research.

The A549 cell lines are the most commonly used human non-small cell lung cancer cell lines for both basic research and drug discovery. In this article, we will cover every topic about this cell line, ranging from general information to research applications.

A549 is the most commonly used human non-small cell lung cancer cell line for basic research and drug discovery. The A549 cell line consists of hypotriploid alveolar basal epithelial cells. This cell line was first developed by D. J. Giard et al. in 1972 by removing and culturing pulmonary carcinoma tissue from the explanted tumor of a 58-year ...

An A549 cell is a type of human alveolar basal epithelial cell that is squamous in nature and plays a role in the diffusion of substances across the alveoli of the lungs. AI generated definition based on: Electroporation-Based Therapies for Cancer, 2014

The A549 cell line, emblematic of human non-small cell lung cancer, originates from the adenocarcinoma subtype within the alveolar epithelial cells. These cells offer a versatile model for a wide array of investigations in cancer biology, toxicology, and immuno-oncology.

Characteristics: Expresses HPRT1 at the surface of the cell membrane (PubMed= 28408844). Virology: Highly susceptible to infection by Zika virus (ZIKV) (PubMed= 29468137).

We examined A549 cell growth in different media over long term culture and then used microarray analysis to investigate temporal regulation of pathways involved in cell cycle and ATII differentiation; we also made comparisons with gene expression in …

A549 cells are a well-characterized standard among the human lung carcinoma/alveolar cell lines used in molecular biology. The A549 cells stored at the NIH were tested under the guidance of the FDA’s cGMP regulations and may be suitable for producing adenoviruses that can be used in clinical trials and analyzing adenoviral-based therapies and ...

Jun 19, 2023 · A549 is a human lung adenocarcinoma cell line that was derived from a male patient in 1972. It is commonly used as a model for studying lung cancer and respiratory diseases. A549 cells have several characteristics that …