A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines established from solid tumors by D.J. Giard, et al. and can be used in cancer, toxicology, and immuno-oncology research.

A431 cells are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). They are often used as a positive control for EGFR expression.

A431 cells overexpress epidermal growth factor receptor (EGFR). They serve as a positive control for studying EGFR signalling and its implications in cancer. They are also used to evaluate new cancer therapies.

Culture of A-431 human epidermoid carcinoma cells in serum-free medium: effect of culture conditions on the binding of [125I]-epidermal growth factor. Different responses to EGF in two human carcinoma cell lines, A431 and UCVA-1, possessing high numbers of EGF receptors.

Sep 3, 2021 · S7 ADC treatment induced much higher apoptosis of A431 and MDA-MB-468 cells and triggered a substantial dose-dependent shift of tumor cell cycle from G1 phase to G2/M phase with respect to 97m ...

The A-431 cell line, which was derived from an epidermoid carcinoma excised from the skin tissue of an 85-year-old female, is one of a succession of cell lines established from solid tumors by a research team led by D. J. Giard.

A431 is a human epidermoid carcinoma cell line that was originally derived from a skin biopsy of a patient with vulvar squamous cell carcinoma. It is commonly used as a model for studying the biology of epithelial cancers, particularly those of the skin and mucous membranes.

A431NS was derived from the A431 cell line (ATCC CRL-1555) in 1997 by repeated subculturing to select cells that detached from the substrate easily.

Epidermal growth factor (EGF) at 3 nM maximally inhibits the proliferation of A431 epidermoid carcinoma cells. We show that at lower concentrations, in the range of 3-100 pM, EGF has a mitogenic effect on A431 cells.

The epidermoid carcinoma cell line A431 expresses abnormally high levels of epidermal growth factor receptor (EGFR) and is a useful model for studying EGFR-mediated signaling, which regulates growth, survival, proliferation, and differentiation in mammalian cells.