It plays a role in regulating transcription by controlling the positive transcription elongation factor P-TEFb. [2] 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the complex.

The protein composition of the 7SK small nuclear ribonucleoprotein (snRNP) is regulated dynamically. Whereas the La related protein LARP7 is a constitutive component, the methyl phosphate capping enzyme MePCE associates secondarily …

May 6, 2016 · In this review, we discuss mechanisms of 7SK snRNP recruitment to promoter-proximal regions and P-TEFb disassembly from the inhibitory snRNP to regulate ‘on site' kinase activation and Pol II pause release. KEYWORDS: KAP1, P-TEFb, RNA polymerase II, transcription elongation, 7SK snRNP.

Mar 2, 2017 · 7 SK sn RNP is a bifunctional RNAPII ‐specific transcriptional regulatory factor that controls both mRNA production and sn (o) RNA s synthesis. The human 7SK snRNA is an abundant RNA polymerase III (RNAPIII)‐transcribed nucleoplasmic RNA (Diribarne & …

Feb 24, 2021 · We found that Smn interacts with the 7SK core components Larp7 and Mepce and specifically associates with 7SK subcomplexes containing hnRNP R. The association between Smn and 7SK complexes is...

Jun 6, 2017 · To examine the complex interactions within the 7SK snRNP we set out to assemble a functional 7SK snRNP in vitro. Using a combination of biochemical techniques, recombinant RNA and proteins, we were able to analyze these interactions in detail.

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding …

Oct 10, 2023 · Human 7SK is an abundant and conserved 332-nucleotide small nuclear RNA (snRNA) that inhibits transcription elongation through negatively regulating P-TEFb kinase activity. 10,11,12 Specifically, 7SK forms small nuclear ribonucleoprotein (snRNP) complexes with several RNA-binding proteins to modulate RNA Pol II promoter-proximal pausing.

Aug 8, 2007 · In cooperation with HEXIM1, the 7SK snRNA sequesters P-TEFb into the kinase-inactive 7SK/HEXIM1/P-TEFb small nuclear ribonucleoprotein (snRNP), and thereby, controls the nuclear level of active P-TEFb.

Sep 17, 2013 · Our study indicates that a single non-coding RNA, the snRNA 7SK, is a gatekeeper of transcriptional termination and bidirectional transcription in embryonic stem cells and mediates transcriptional poising through a mechanism independent of chromatin bivalency.