The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed …

Entities that are capable of exerting an antagonistic effect on 5-HT1A receptors. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in …

Jul 4, 2003 · In 1993, one of us (F.A.) proposed that “5-HT 1A receptor antagonists could accelerate (and perhaps augment) the clinical effects of antidepressants by preventing this …

Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the …

Serotonin (5-hydroxytryptamine, 5–HT) is a key mediator in the physiology of mood, vascular function and gastrointestinal motility. This explains the number of therapeutic agents that act …

Newer “atypical” psychotics primarily serve as antagonists at the 5-HT 2A and D 2 receptors; however, they also select for a cohort of other receptors with varying binding affinities.

5-HT1A antagonists refer to compounds that block the 5-HT1A receptor, leading to enhanced glutamatergic transmission and improved cognition by removing the inhibitory effects of …

Oct 3, 2011 · Although no 5-HT 1A antagonists have been launched, previous studies have shown that 5-HT 1A receptor antagonists may be useful in the treatment of Alzheimer's …

A wealth of evidence implicates the serotonin 1A (5-HT1A) receptor in the pathophysiology of depression. Stimulation of the 5-HT1A receptor is an existing therapeutic target for treating …

May 5, 2015 · Co-administration of the 5-HT1A receptor (5-HT1AR) antagonist WAY-100635 reversed the negative effects of acute fluoxetine, a serotonin reuptake inhibitor, but not …