In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA. This process, known as mRNA …

The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades of research have established that the m7G cap serves as a unique molecular module that …

Mar 17, 2025 · The 5′ cap, a modified guanosine nucleotide, protects against exonucleases and facilitates ribosome recognition. This cap, a 7-methylguanosine (m7G) linked via a 5′-5′ …

The 5′ cap is guanosine with a methyl group on the 7-position; this modified nucleoside is often abbreviated as m7G. The cap connects via triphosphate linkage (PPP) to the first nucleotide at …

Mar 11, 2025 · The 5′ cap of mRNA is instrumental in initiating translation, acting as a recognition element for the ribosomal machinery. This cap structure is the first point of contact for the …

Jun 22, 2020 · The 5’ cap protests the newly-synthesized mRNA from degradation. It also assists in ribosome binding to help initiating translation. 3’ poly-A tail protects mRNA from …

Sep 19, 2016 · The 5' m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades of research have established that the m7G cap serves as a unique molecular module …

Post-transcriptional processing of the 5' end of the RNA product of DNA transcription comes in the form of a process called the 5' cap. At the end of transcription, the 5' end of the RNA transcript …

May 1, 2019 · The mRNA 5ʹ cap regulates splicing, nuclear export, resistance to exonuclease degradation, and translational initiation. The cap also marks the mRNA to the innate immune …

May 30, 2024 · The 5′ cap (cap-0) at the 5′ end of an mRNA molecule in eukaryotes consists of a guanine nucleotide linked to the mRNA through an unique 5′ to 5′ triphosphate bond. A …