CD137 - Wikipedia
CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. [5][6] Its alternative …
4-1BB immunotherapy: advances and hurdles - Nature
Jan 4, 2024 · Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated …
4-1BB (CD137), an inducible costimulatory receptor, as a …
Immunotherapy targeting CD8 + T cells by agonistic anti-4-1BB (CD137) monoclonal antibody (mAb) aptly fits these requisites. 4-1BB, a member of the tumor necrosis factor receptor …
4-1BB: A promising target for cancer immunotherapy - PMC
Stimulation of 4-1BB, a surface receptor expressed on activated T cells amongst many other types of immune cells, activates various signaling pathways involved in the generation of a …
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results ...
Jan 4, 2018 · Agonistic monoclonal antibodies targeting 4-1BB have been developed to harness 4-1BB signaling for cancer immunotherapy. Preclinical results in a variety of induced and …
4-1BB Antibodies in Oncology Clinical Trials: A Review - PMC
The ability of 4-1BB to stimulate cytotoxic T-cell responses makes it a promising target for therapeutic cancer immunotherapy development. 4-1BB antibodies have shown promising …
4-1BB as a Therapeutic Target for Human Disease
4-1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4-1BB agonistic antibody treatment in …
Immunotherapy of cancer with 4-1BB - PubMed
4-1BB (CD137), a member of the TNF receptor superfamily, is an activation-induced T-cell costimulatory molecule. Signaling via 4-1BB upregulates survival genes, enhances cell …
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical …
On NK cells, 4-1BB signaling can increase antibody-dependent cell-mediated cytotoxicity. Agonistic monoclonal antibodies targeting 4-1BB have been developed to harness 4-1BB …
Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated immune functions....