In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.

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Because IKK and IKK related kinases play a crucial role in the NF-κB activation pathway, several inhibitors have been developed against these kinases for cancer therapy. Since IKKβ is the primary regulator of NF-κB, most inhibitors are based …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for ...

In this review we will focus on p50/p65 NF-κB and IRF3, whose activation involves specific members of the inhibitor of κB (IκB) kinase (IKK) family. The canonical IKKs, IKKα and IKKβ, form a complex with the adaptor protein NEMO (also known as IKKγ), which has a regulatory role.

Apr 14, 2003 · To identify potential downstream targets of IKKε and TBK1, we have analyzed in detail the effect of these kinases on the expression of genes encoding IFN-β and RANTES.

It is a Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling.

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC 50 s of 45 and 650 nM for IKKβ and IKKα, respectively.

Dec 26, 2012 · Biological assembly 1 assigned by authors and generated by PISA (software)