LY-341495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR 2/3).

LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2, mGlu 3, mGlu 8, mGlu 7a, mGlu 1a, mGlu 5a and mGlu 4a receptors respectively).

In this study, we found that the metabotropic glutamate receptor (mGluR) 2/3 was expressed on MDSCs, and an mGluR2/3 antagonist LY341495 attenuated the immunosuppressive activity of MDSCs. Furthermore, we observed that LY341495 treatment inhibited B16 …

LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50 s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively [5]. LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats [1].

Here, we examine the effect of LY341495 inhibition of mGluR2 and mGluR4 signaling, group II and III mGluRs, respectively. We find that paradoxically, despite the selectivity of the compound for mGluR2 signaling, its application may lead to effects of these receptors being more difficult to distinguish. 2. MATERIALS AND METHODS. 2.1.

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In particular, LY341495 is the most potent antagonist yet reported at mGlu2, 3 and 8 receptors. Thus, it represents a novel pharmacological agent for elucidating the function of mGlu receptors in experimental systems.

View and buy high quality LY 341495 disodium salt. Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209). Cited in 8 publications.