Cyrius is a tool to genotype CYP2D6 from a whole-genome sequencing (WGS) BAM file. Cyrius uses a novel method to solve the problems caused by the high sequence similarity with the …

Jan 19, 2021 · We present a new software tool, Cyrius, that accurately genotypes the highly complex CYP2D6 region. Across the 144 validation samples, we are able to confirm the …

Jan 18, 2021 · Here we describe Cyrius, a novel WGS-specific CYP2D6 genotyping tool that overcomes the challenges with the homology between CYP2D6 and CYP2D7 and works for …

Jan 18, 2021 · Here we describe Cyrius, a novel WGS-specific CYP2D6 genotyping tool that overcomes the challenges with the homology between CYP2D6 and CYP2D7 and works for …

Cyrius, a CYP2D6 ‐specific tool, demonstrated the most robust performance, achieving the highest concordance rates for CYP2D6 in all instances, comparable to the consensus …

Here we describe a novel bioinformatics method, Cyrius, that accurately genotypes CYP2D6 using whole-genome sequencing (WGS) data. We show that Cyrius has superior performance …

CYP2D6 metabolizes 21% of clinically used drugs. Cyrius resolves common SVs and sequence homology to paralog and genotypes CYP2D6 with 99.3% accuracy.

Hello there, while testing Cyrius v1.1.1 on CYP2D6-calling on samples from GeT-RM I encountered something unexpected. On a publication that used Cyrius v1.1, sample NA18565 …

Feb 14, 2025 · Cyrius was Chemosian by birth, inducted into the Emperor's Children Legion after Fulgrim's rediscovery. He quickly earned a reputation as an excellent swordsman and …

Feb 3, 2025 · Among these, Cyrius, a tool specifically designed for CYP2D6 genotyping, has demonstrated high performance across various datasets. However, Cyrius has not been …