May 7, 2020 · Over the last 10 years, 18 F-sodium fluoride (18 F-NaF) positron emission tomography (PET) has emerged as a noninvasive quantitative imaging modality capable of imaging calcification activity in the vasculature.

Apr 3, 2020 · Fluorine-18-labeled sodium fluoride (also known as 18F-NaF or sodium fluoride) is a PET radiotracer used primarily for skeletal imaging. Fluorine-18-labeled sodium fluoride is an ionic compound comprised of a single sodium atom bound to a positron-emitting isotope of fluorine.

Jun 1, 2021 · 18F-NaF PET/CT is indicated for diagnostic imaging of bone to define altered osteogenic areas of activity. It provides high-resolution, high-contrast images of the skeletal tissue and has higher sensitivity, specificity, and accuracy than conventional nuclear bone scintigraphy.

Mar 1, 2020 · Continued development of PET scanners has opened a new era for 18F-NaF, and given its higher sensitivity, there have been increasing applications in imaging. In this review, we will discuss the history, technical aspects, radiobiology, and biodistribution of this tracer.

icology After intravenous injection, 18F is rapidly cleared from the blood stream in a bi-exponential fashion (T1/2 = 0.4h and 2.6h) and essentially all 18F delivered to bone capillaries and the …

Nov 1, 2010 · 18 F is a diagnostic molecular imaging agent used for identification of new bone formation. 18 F, administered as intravenous Na 18 F, was approved by the U.S. Food and Drug Administration in 1972 but has been listed as a discontinued drug since 1984.

Sodium Fluoride F 18 Injection, a positron-emitting radiopharmaceutical containing no carrier-added (NCA) radioactive fluoride 18F, is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging. Sodium Fluoride F 18 Injection is indicated as a bone imaging agent to define areas of altered osteogenic activity.

With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively.

Jul 22, 2021 · 18 F-sodium fluoride (18 F-NaF) positron emission tomography/computed tomography (PET/computed tomography [CT]) is a promising noninvasive imaging tool for visualizing active calcification in plaques. 1 Calcifications first appear in progressive lesions near lipid pools and necrotic areas, 2 and 18 F-NaF PET may, therefore, provide information ...

Jul 7, 2015 · We show that 18 F-NaF adsorbs to calcified deposits within plaque with high affinity and is selective and specific. 18 F-NaF PET/CT imaging can distinguish between areas of macro- and...